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Dhanapal, C. K.
- Anti-alzheimer's Activity of Aqueous Extract of Leaves of Murraya koenigii in Aluminium Chloride Induced Neurotoxicity in Rats
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Authors
Affiliations
1 Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally, Maisamaguda, Secunderabad 500100, Medchal, Telangana, IN
2 Department of Pharmacy, Annamalai University, Chidambaram, T.N., IN
1 Department of Pharmacology, Malla Reddy College of Pharmacy, Dhulapally, Maisamaguda, Secunderabad 500100, Medchal, Telangana, IN
2 Department of Pharmacy, Annamalai University, Chidambaram, T.N., IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1927-1934Abstract
Objective: The present study was aimed to evaluate the protective effect of Murraya koenigii on aluminium chloride (AlCl3) induced neurobehavioral and pathological changes in Alzheimeric rats. Methods: Wistar albino rats were selected in this study and were divided into 6 groups (6each). Group I animals received saline and were considered as control. Group II rats were administered with AlCl3 (40mg/kg b.w, oral) for 35 days. Group III rats were treated with standard Vitamin E (100mg/kg b.w, p.o) and AlCl3 (40mg/kg b.w, oral). Group IV, V,VI received aqueous extract of leaves of Murraya koenigii (100mg/kg b.w, p.o,200mg/kg b.w, p.o,400mg/kg b.w, p.o) and inducing agent AlCl3 (40mg/kg b.w, oral) .The rats were given respective treatment for 35 days and behavioural parameters were determined on the 35th day. On the 35th day the rats were sacrificed and anti-oxidant parameters, brain acetylcholinesterase content were determined. Results: Oral administration of aqueous extract of leaves of Murraya koenigii at doses 100,200, 400mg/kg body weight showed improvements in behavioural parameters when compared to AlCl3 induced rats; showed increase in superoxide dismutase, catalase, reduced glutathione and decreased levels of malondialdehyde and also a showed decrease in brain acetylcholinesterase content when compared to AlCl3 induced rats. Conclusion: This study strongly suggested that M koenigii could possibly restore the altered neurological capacities and antioxidant power in rats, and it could even be a good alternative to chemical medicines against AlCl3 induced neurotoxicity.Keywords
Alzheimer’s Disease, Alcl3, Antioxidant parameters, Behavioural parameters, Murraya koenigii.
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